| 1 | Sun, Sep 7 | vs Baltimore | 8:20 PM | NBC |
| 2 | Sun, Sep 14 | @ New York Jets | 1:00 PM | CBS |
| 3 | Thu, Sep 18 | vs Miami | 8:15 PM | Prime Video |
| 4 | Sun, Sep 28 | vs New Orleans | 1:00 PM | CBS |
| 5 | Sun, Oct 5 | vs New England | 8:20 PM | NBC |
| 6 | Mon, Oct 13 | @ Atlanta | 7:15 PM | |
| 7 | BYE WEEK | |||
| 8 | Sun, Oct 26 | @ Carolina | 1:00 PM | FOX |
| 9 | Sun, Nov 2 | vs Kansas City | 4:25 PM | CBS |
| 10 | Sun, Nov 9 | @ Miami | 1:00 PM | CBS |
| 11 | Sun, Nov 16 | vs Tampa Bay | 1:00 PM | CBS |
| 12 | Thu, Nov 20 | @ Houston | 8:15 PM | Prime Video |
| 13 | Sun, Nov 30 | @ Pittsburgh | 4:25 PM | CBS |
| 14 | Sun, Dec 7 | vs Cincinnati | 4:25 PM | FOX |
| 15 | Sun, Dec 14 | @ New England | 1:00 PM | CBS |
| 16 | Sun, Dec 21 | @ Cleveland | 1:00 PM | CBS |
| 17 | Sun, Dec 28 | vs Philadelphia | 4:25 PM | FOX |
| 18 | TBD-Flex Game | vs New York Jets | TBD |
Buffalo Bills 2025 Schedule
May 15, 2025 | 6:14 AM
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Buffalo, NY, USA
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